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Toxicological Risk Assessment Of Chemicals

Author : Elsa Nielsen
ISBN : 0849372658
Genre : Medical
File Size : 89. 35 MB
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Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk assessment of chemical substances. It illustrates each step in the process: hazard identification, a dose response assessment, and exposure assessment. The book also summarizes the basic concepts of interaction of chemicals in mixtures and discusses various approaches to testing such mixtures. Features: Addresses standards from all international regulatory agencies Presents the steps in risk assessment, including hazard identification, exposure assessment, and risk characterization Covers the assessment of multiple chemical exposures or chemical mixtures Contains data from both human and animal studies Explains the linearized multi-stage mathematical model widely used by the US EPA for characterizing

Toxicological Risk Assessment Of Chemicals

Author : Elsa Nielsen
ISBN : 9781420006940
Genre : Medical
File Size : 59. 93 MB
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Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk

A Practical Guide To Toxicology And Human Health Risk Assessment

Author : Laura Robinson
ISBN : 9781118882023
Genre : Science
File Size : 56. 61 MB
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Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author's training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.

A Practical Guide To Understanding Managing And Reviewing Environmental Risk Assessment Reports

Author : Sally L. Benjamin
ISBN : 9781420026276
Genre : Law
File Size : 31. 14 MB
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A Practical Guide to Understanding, Managing and Reviewing Environmental Risk Assessment Reports provides team leaders and team members with a strategy for developing the elements of risk assessment into a readable and beneficial report. The authors believe that successful management of the risk assessment team is a key factor is quality repor

Toxicological Risk Assessment And Multi System Health Impacts From Exposure

Author : Aristidis M. Tsatsakis
ISBN : 9780323853583
Genre : Medical
File Size : 75. 37 MB
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Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. • Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field • Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease • Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research

Practical Guide To Chemical Safety Testing

Author : Derek J. Knight
ISBN : 185957372X
Genre : Science
File Size : 28. 95 MB
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Annotation This book describes the different tests that must be performed on new chemicals and other materials to demonstrate to the regulatory authorities that they are safe for use. Tests vary from physico-chemical, measuring properties such as melting point and density, through genetic toxicity studies, to mammalian toxicology and studies to investigate effects on the environment. This book describes clearly the process of obtaining approval for use in a variety of global regions and across different applications. It also explains why different tests are performed and the implications of the results.

Information Resources In Toxicology

Author : Steve Gilbert
ISBN : 9780128137253
Genre : Medical
File Size : 78. 59 MB
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This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools. Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology’s presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field. The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children’s environmental health. Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources. Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles. Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals. Explores recent internet trends, web-based databases, and software tools in a section on the online environment. Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents. Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field.

Information Resources In Toxicology

Author : P.J. Bert Hakkinen
ISBN : 0080920039
Genre : Science
File Size : 87. 36 MB
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This latest version of Information Resources in Toxicology (IRT) continues a tradition established in 1982 with the publication of the first edition in presenting an extensive itemization, review, and commentary on the information infrastructure of the field. This book is a unique wide-ranging, international, annotated bibliography and compendium of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. Thoroughly updated, the current edition analyzes technological changes and is rife with online tools and links to Web sites. IRT-IV is highly structured, providing easy access to its information. Among the “hot topics covered are Disaster Preparedness and Management, Nanotechnology, Omics, the Precautionary Principle, Risk Assessment, and Biological, Chemical and Radioactive Terrorism and Warfare are among the designated. • International in scope, with contributions from over 30 countries • Numerous key references and relevant Web links • Concise narratives about toxicologic sub-disciplines • Valuable appendices such as the IUPAC Glossary of Terms in Toxicology • Authored by experts in their respective sub-disciplines within toxicology

Toxicological Risk Assessment For Beginners

Author : José A. Torres
ISBN : 9783319127514
Genre : Medical
File Size : 85. 88 MB
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This book serves as a comprehensive introductory guide to the practical aspects of risk assessment. Chapters include clearly defined objectives and summaries. The book includes: hazard identification, dose-response, exposure assessment, risk characterization, chemical mixtures, epidemiology, emerging issues and global perspectives with accessible language. The book concludes with a set of hypothetical case studies. Toxicological Risk Assessment for Beginners aims not to create an expert, but rather to provide readers with their first understanding of the risk assessment topic. This book was designed with the student in mind. We simplify a complex process for beginners and balance theory with practical aspects, but remain fluid enough to increase difficulty with case studies. By incorporating an action based, step by step approach to learning the risk assessment process, this book provides its readers with an elementary understanding of how the risk assessment process is initiated, developed and finished, making it a valuable guide for graduate students, post-doctoral fellows and early career scientists in industry.

Hayes Principles And Methods Of Toxicology

Author : A. Wallace Hayes
ISBN : 9781842145371
Genre : Medical
File Size : 74. 45 MB
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Hayes' Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chap

Principles And Methods Of Toxicology

Author : A. Wallace Hayes
ISBN : 9781420005424
Genre : Medical
File Size : 27. 2 MB
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Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanis

Practical Toxicology

Author : David Woolley
ISBN : 1498709281
Genre :
File Size : 57. 22 MB
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Preceded by A guide to practical toxicology: evaluation, prediction, and risk / Adam Woolley. 2nd ed. c2008.

Chemical Risk Assessment

Author : Peter Fisk
ISBN : 9781118684078
Genre : Science
File Size : 55. 70 MB
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This book is an essential guide and support to understanding of the science and policy, procedure and practice that underpins the REACH risk assessments required for the use and placing on the market of chemicals in the European Union. A clear understanding of information provision and how this affects the assessment of chemical safety is fundamentally important to the success of policy on chemicals and ultimately to the sustainability of the chemicals industry. Within the book, the scientific processes that underpin the policy are explained in a practical way. Importantly, it includes coverage of techniques to help solve the problems of using potentially risky and hazardous chemicals through the use of less hazardous alternatives and ‘green chemistry’, and also the analysis of the risks of the use of the most hazardous substances against the social and economic benefits of use. Chemical Risk Assessment: A Manual for REACH covers the following main themes: i) Assessment of chemical risk; ii) Risk management; iii) Hazard reduction, substitution and green chemistry; iv) Risk versus benefit – socio-economic analysis. The book acts as a practical guide and overview to chemicals risk assessment and risk management (in the EU context), as well as a support text for planning for the challenges of the future, which will see ever-increasing pressure to withdraw hazardous substances from the EU (and global) market, balanced against opportunities for innovation in the development of less hazardous chemicals.

Practical Toxicology

Author : David Woolley
ISBN : 9781498709323
Genre : Medical
File Size : 21. 55 MB
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Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition shows how to conduct a program of safety evaluation and testing and then to interpret and apply the resulting data and information in the real world, beginning with the basic concepts in toxicology and progressing to the interpretation of the resulting data. Revised and updated chapters on risk assessment guide the reader to setting the foundations necessary for submission to regulatory authorities. In addition, a new chapter in the book reviews the errors in toxicology, mistakes, misuse, mismanagement, and misunderstanding with a view to avoiding these in the future. New Chapters in the Third Edition: Toxicology in silico Errors in Toxicology Safety Assessment of Extractables and Leachables. This new edition follows a practical sequence from introducing the basics of toxicology (including the vital concept of normality in controls) to describing a test program and then interpreting the data and translating that to risk assessment that can be used in a number of real world situations where safety and secure risk assessment are essential. Although written primarily from the perspective of pharmaceutical development, the test designs and toxicological problems encountered in that field are entirely relevant to those with other classes of chemicals, the only difference being the regulatory context. Toxicology is an international discipline and the book has been written to take into account some of the differences in regulatory nuance between the main regions of the world. Completely revised and written in an easily accessible style, the text address several audiences—from students and post-graduates coming to the subject for the first time to established professionals who find themselves needing to learn about toxicology, toxicity testing, interpretation of the results, and risk assessment. It is intended primarily as a textbook, with case studies and information on where to go to ask questions, but can also be used as a practical reference book. It covers all the basics of toxicology and the main aspects of safety evaluation testing and risk assessment while reviewing critically the current state of the discipline. It also provides a foundation for those seeking registration or certification.

A Guide To Practical Toxicology

Author : David Woolley
ISBN : 9781420043150
Genre : Medical
File Size : 37. 52 MB
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This practical, user-friendly, and informative text surveys basic principles of toxicology. It is an invaluable guide to evaluating toxicity and related data, approaching toxicity testing and interpretation, and understanding the concepts of hazard prediction and risk assessment and management. A Guide to Practical Toxicology: examines how to evaluate various groups of chemicals—pharmaceuticals, cosmetics, and agrochemicals provides insights on toxicity determination, normality and naturality, prediction, and regulation Two all-new chapters cover: safety pharmacology evaluation of different chemical classes

The British National Bibliography

Author : Arthur James Wells
ISBN : STANFORD:36105211722686
Genre : Bibliography, National
File Size : 69. 27 MB
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Air Toxics And Risk Assessment

Author : Edward J. Calabrese
ISBN : 0873711653
Genre : Nature
File Size : 27. 65 MB
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Unlike most books, this one actually does risk assessments for you for over 110 chemicals that are confirmed or probable air toxics. All chemicals are analyzed with a scientifically sound methodology-outlined in the book-to assess public health risk associated with exposure to air toxics. Methodology will allow you to properly handle all air toxic health concerns within a practical decision-free framework. This permits the application of methodology to any new chemical. Each chemical or compound is organized by synonym, molecular weight, molecular formula, AALG, occupational limits, drinking water limits, toxicity profile and indexed by CAS number, and synonyms.

Handbook Of Occupational Safety And Health

Author : Louis J. DiBerardinis
ISBN : UOM:39015046909282
Genre : Science
File Size : 62. 59 MB
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Workplace safety and health is serious business. In work environments where the safety and health of employees is a significant issue, a major leadership challenge is to instill shared, companywide values that establish the safety, health, and well-being of each individual as a paramount concern of the business. Now in its second edition, the Handbook of Occupational Safety and Health, originally edited by Lawrence Slote, remains an essential first source for quick, practical answers on this pivotal workplace issue. Concise chapters detail specific issues of biological, chemical, and physical hazards to workplace safety and health, and also address a broad spectrum of management concerns including training, workers' compensation, liability coverage, and regulatory matters. While adhering to the requirements set by the Occupational Safety and Health Act (OSHA) of 1971, the authors of this volume advocate a progressive approach that exceeds basic compliance with established regulations. Chapters emphasize not only worker protection through safe equipment and management supervision, but also the safety training of workers. Throughout, contributors stress the need to align safety and health concerns fully with a company's business objectives, offering insight into how these dual interests can be integrated. With many chapters structured in an accessible "how-to" format, even those professionals inexperienced in occupational safety issues can rapidly gain a practical knowledge of the particular concerns of their industry. For launching or updating a comprehensive workplace safety program, or for assistance with confronting specific problems when they occur, the Handbook is an ideal starting point for assessing risks and initiating proactive measures to prevent accidents in any industry. A new edition of the one-stop source for practical information on occupational safety and health. Now expanded by more than 50 percent, this Second Edition of the Handbook of Occupational Safety and Health, originally edited by Lawrence Slote, demonstrates how to control hazards to safety and health in many types of work environments-and how to deal with injuries when they do occur. It features 30 concise chapters that enable even those not formally trained in occupational safety to get up to speed quickly, plus more than 150 helpful illustrations that complement the text. With up-to-date contributions from occupational physicians, public health professionals, legal experts, and specialists in areas ranging from chemicals and radiation to noise exposure, this comprehensive Handbook presents a complete program of effective responses to a vast range of occupational safety and health problems. It includes: * An overview of the field and its recent advances, with a clear explanation of managerial roles and responsibilities for safety and health * Five sections on a variety of issues-safety evaluations, health assessment, control practices, physical hazards, and legal affairs-that make it simple to pinpoint information quickly * How-to advice-step-by-step guidance on how to conduct an accident investigation, maintain a quality medical surveillance program, and much more * Chapters on the prevention of specific hazards such as dermatoses, heat stress, radiation, respiratory illness,and infection * Includes updated material based on chapters from Patty's Industrial Hygiene and Toxicology, Fourth Edition

Alternatives To Laboratory Animals

Author :
ISBN : UCLA:L0102974995
Genre : Biological models
File Size : 40. 14 MB
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Safety And Health At Work Ilo Cis Bulletin

Author :
ISBN : UOM:39015018816267
Genre : Industrial hygiene
File Size : 77. 54 MB
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