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The Drug Hunters

Author : Donald R. Kirsch
ISBN : 9781628727197
Genre : Science
File Size : 51. 50 MB
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The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.

Managing The Drug Discovery Process

Author : Walter Moos
ISBN : 9780081006320
Genre : Medical
File Size : 37. 99 MB
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Managing the Drug Discovery Process: How to Make It More Efficient and Cost-Effective thoroughly examines the current state of pharmaceutical research and development by providing chemistry-based perspectives on biomedical research, drug hunting and innovation. The book also considers the interplay of stakeholders, consumers, and the drug firm with attendant factors, including those that are technical, legal, economic, demographic, political, social, ecological, and infrastructural. Since drug research can be a high-risk, high-payoff industry, it is important to researchers to effectively and strategically manage the drug discovery process. This book takes a closer look at increasing pre-approval costs for new drugs and examines not only why these increases occur, but also how they can be overcome to ensure a robust pharmacoeconomic future. Written in an engaging manner and including memorable insights, this book is aimed at redirecting the drug discovery process to make it more efficient and cost-effective in order to achieve the goal of saving countless more lives through science. A valuable and compelling resource, this is a must-read for all students and researchers in academia and the pharmaceutical industry. Considers drug discovery in multiple R&D venues, including big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable

Job In The Drug Indutry

Author : Richard J. Friary
ISBN : 9780080509624
Genre : Science
File Size : 30. 78 MB
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This book is intended to help newly graduated chemists, particularly organic chemists, at all levels from bachelors to post-doctorates, find careers in the North American pharmaceutical industry. It will serve as a practical, detailed guiedbook for job seekers as well a reference work for faculty advisers, research supervisors, development officers, employment agents, and personnel managers in the industry. The book gathers in a single volume the fundamentals of getting an industrial job as a medicinal or process chemist, and covers all aspects of a chemist's job--scientific, financial, and managerial--within a pharmaceutical/biotechnology company. Other scientists looking for jobs as analytical or physical chemists and even biochemists and biologists will find the book useful. The valuable appendix is a unique compendium of 365 commercial, governmental, or non-profit institutions that comprise the North American pharmaceutical industry. Learn How To: Discover the 12 permanent, big-pharma jobs for B.S. chemists Use the 500+ company index to locate potential employers Track pharma openings with 190+ corporate and chemist-specific job banks Add industry veterans to your employment network Find the 50+ companies offering paid summer internships to students Include the one resume item that wins interviews for B.S. and M.S. chemists Express a knowledgeable preference for drug discovery or development Research over 360 drug companies through their Web sites Discover the 70+ firms offering stock purchase plans or stock options3⁄4and which two represent big pharma Find out your salary offer in time to negotiate your wages

The Drug Makers A Story From Inside The Pharmaceutical Business

Author : David M. Shlaes
ISBN : 9781483431857
Genre : Science
File Size : 42. 49 MB
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Daniel Simon leaves his job as a professor at a Midwestern medical school to work in the pharmaceutical industry because he wants to make a greater and more direct impact in his field. But he soon finds that in his new role, he must contend with petty crooks, fraudsters, and brilliant but money-hungry researchers. There’s also the U.S. Food and Drug Administration, which seeks to put a regulatory death to what could be lifesaving antibiotics. Whether he’s working at a large company, small company or biotechnology company, he sees how they make decisions, conduct research, and earn revenue. Sometimes, he gets caught in turf battles and must deal with inflated egos. With a career and family to think about, Daniel works hard to bring new antibiotics to the market, but he becomes increasingly frustrated by the hurdles that must be overcome. He has his work cut out for him in The Drug Makers.

Polypharmacology In Drug Discovery

Author : Jens-Uwe Peters
ISBN : 9780470590904
Genre : Medical
File Size : 60. 94 MB
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"Covers the two-sided nature of polypharmacology--its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes. Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology"--Provided by publisher.

Drug Discovery And Drug Development

Author : Madhu Dikshit
ISBN : 9789811580024
Genre : Medical
File Size : 30. 38 MB
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Over the years, India has attained a prominent global position in the manufacture of Generic Drugs. This success can be attributed to its synthetic organic chemistry and chemical engineering strengths, nurtured by the timely policies of the Government of India. However, breakthrough successes in New Drug Discovery have remained elusive, despite the brilliant and sustained efforts of many Indian researchers and Pharma establishments. The Indian National Science Academy thought it appropriate to document India’s New Drug Discovery Research (NDDR) journey to date. Gathering contributions from prominent researchers in the Indian Pharma Industry and Academia, this book highlights their efforts, achievements, and the status quo of Indian NDDR.

Adme Enabling Technologies In Drug Design And Development

Author : Donglu Zhang
ISBN : 9780470542781
Genre : Medical
File Size : 52. 91 MB
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This book comprehensively covers the state-of-the-art and cutting-edge technologies in an integrated fashion for applications in ADME studies of small molecular drugs. Each chapter provides descriptions of the technologies, application scope and limitations, optimal conditions for intended results, protocols, case studies, and future developments. By concisely describing these technologies, the book provides a useful tool for drug metabolism scientists and as a reference for scientists in the fields of pharmacology, medicinal chemistry, pharmaceutics, toxicology, bioanalytical science in academia and industry.

Transporters As Drug Carriers

Author : Gerhard F. Ecker
ISBN : 352762743X
Genre : Science
File Size : 21. 10 MB
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This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion. As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general. For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.

Advancements In Controlled Drug Delivery Systems

Author : Verma, Shekhar
ISBN : 9781799889090
Genre : Medical
File Size : 33. 85 MB
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The many drawbacks of conventional dosage forms and delivery systems are overcome by designing and developing controlled release drug delivery systems, and pharmaceutical and other scientists have carried out extensive and intensive investigations in the field to explore their applications. A controlled-release drug formulation can improve product efficacy and extend patent protection. As controlled drug delivery systems continue to play a vital role in delivering various types of therapeutic agents in a controlled manner, researchers are only just scratching the surface of their full potential. Advancements in Controlled Drug Delivery Systems supplies information on translating the physicochemical properties of drugs into drug delivery systems, explores how drugs are administered via various routes, and discusses recent advancements in the fabrication and development of controlled drug delivery systems. It also underlines the methodology of controlled drug delivery system preparation and the significance, disadvantages, detailed classifications, and relevant examples. Covering topics such as machine learning and oral-controlled drug delivery, this book is ideal for pharmacists, healthcare professionals, researchers, academicians, research centers, health units, students, and pharmaceutical and scientific laboratories.

Pharmacological Advances In Natural Product Drug Discovery

Author : Guanhua Du
ISBN : 9780128201855
Genre :
File Size : 37. 63 MB
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Pharmacological Advances in Natural Product Drug Discovery, Volume 87 in the Advances in Pharmacology series, presents the latest pharmacological research progresses of 8 medicinal compounds from natural products, including salvianolic acid, tanshinone, paeonol, chlorogenic acid, astragaloside, icariin, ganoderan, and febrifugine. Specific chapters to this new release include Potential Role of Paeonol on Atherosclerosis Related Cells, A Review on Salvianolic Acid, Pharmacological Advances of Tanshinones, the Natural Product of Salvia Miltiorrhiza, Pharmacological Action and Potential Targets Analysis of Major Pharmacological Effects of Chlorogenic Acid, Modern TCM: Identifying and Defining the "Medicinal Mix", Pharmacological Advances in Astragaloside IV Derived from Astragalus Membranaceus, and much more. Includes the authority and expertise of leading contributors in natural product pharmacology Provides the latest pharmacological research progresses of eight medicinal compounds from natural products Presents a thorough discussion on the compatibility of traditional medicines

Kinetics Of Enzyme Action

Author : Ross L. Stein
ISBN : 1118084403
Genre : Science
File Size : 38. 31 MB
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Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery.

Uk Drugs Unlimited

Author : H. Parker
ISBN : 9781403919861
Genre : Social Science
File Size : 33. 71 MB
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The appetite for illicit drugs in the UK continues to grow and diversify. Young Britons consume more drugs than their peers anywhere else in Europe. Why and how has this happened and why have all official efforts to stem drug 'abuse' so far failed. Will the new UK drugs strategy fair any better? This unique collection of contemporary studies from the frontline by a leading social research group describes the drugs landscape in an accessible and authoritative way.

Ten Drugs

Author : Thomas Hager
ISBN : 9781683355311
Genre : Medical
File Size : 73. 7 MB
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“The stories are skillfully told and entirely entertaining . . . An expert, mostly feel-good book about modern medicine” from the award-winning author (Kirkus Reviews, starred review). Behind every landmark drug is a story. It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine. Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book. “[An] absorbing new book.” —The New York Times Book Review “[A] well-written and engaging chronicle.” —The Wall Street Journal “Lucidly informative and compulsively readable.” —Publishers Weekly “Entertaining [and] insightful.” —Booklist “Well-written, well-researched and fascinating to read Ten Drugs provides an insightful look at how drugs have shaped modern medical practices. Towards the end of the book Hager writes that he ‘came away surprised by some of the things he had learned.’ I had the very same reaction.” —Penny Le Couteur, coauthor of Napoleon’s Buttons: How 17 Molecules Changed History

Drug Discovery And Clinical Research

Author : SK Gupta
ISBN : 9789350900338
Genre :
File Size : 28. 88 MB
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Drug Discovery And Development E Book

Author : Raymond G Hill
ISBN : 9780702053160
Genre : Medical
File Size : 47. 74 MB
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The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. New topic - DMPK Optimization Strategy in drug discovery. New chapter on Scaffolds: Small globular proteins as antibody substitutes. Totally updated chapters on Intellectual Property and Marketing 50 new illustrations in full colour Features Accessible, general guide to pharmaceutical research and development. Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. Written by a strong team of scientists with long experience in the pharmaceutical industry. Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: ‘... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. Highly Commended in the medicine category of the BMA 2006 medical book competition Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year

Biophysical And Computational Tools In Drug Discovery

Author : Anil Kumar Saxena
ISBN : 9783030852818
Genre : Science
File Size : 42. 26 MB
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This book reviews recent physicochemical and biophysical techniques applied in drug discovery research, and it outlines the latest advances in computational drug design. Divided into 10 chapters, the book discusses about the role of structural biology in drug discovery, and offers useful application cases of several biophysical and computational methods, including time-resolved fluorometry (TRF) with Förster resonance energy transfer (FRET), X-Ray crystallography, nuclear magnetic resonance spectroscopy, mass spectroscopy, generative machine learning for inverse molecular design, quantum mechanics/molecular mechanics (QM/MM,ONIOM) and quantum molecular dynamics (QMT) methods. Particular attention is given to computational search techniques applied to peptide vaccines using novel mathematical descriptors and structure and ligand-based virtual screening techniques in drug discovery research. Given its scope, the book is a valuable resource for students, researchers and professionals from pharmaceutical industry interested in drug design and discovery.

Sketches Of Cantabs By John Smith Of Smith Hall

Author : John Delaware Lewis
ISBN : OXFORD:590601253
Genre :
File Size : 62. 29 MB
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Sketches Of Cantabs With Two Illustrations By Hablot K Browne Second Edition

Author : John Delaware Lewis
ISBN : BL:A0019641166
Genre :
File Size : 82. 49 MB
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Molecular Aspects Of Dermatology

Author : G. C. Priestley
ISBN : UCLA:L0067722462
Genre : Medical
File Size : 38. 1 MB
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Skin diseases remain a major cause of embarassment, discomfort and incapacity. This book provides a timely and authoritative review of recent developments in the study of the skin and its component molecules. As research begins to move from the protein to the DNA level, biochemists and immunologists are increasingly joined by molecular geneticists.

Real World Drug Discovery

Author : Robert M. Rydzewski
ISBN : 0080914888
Genre : Medical
File Size : 57. 34 MB
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Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher. Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it. Interviews with well-known experts in many of the fields involved, giving insightful comments from authorities on many of the sub-disciplines important to cutting edge drug discovery. Helpful suggestions gleaned from years of experience in biotech and pharma, which represents a repository drug discovery "lore" not previously available in any book. "Periodic Table of Drugs" listing current top-selling drugs arranged by target and laid out so that structural similarities and differences are plain and clear. Extensive use of diagrams to illustrate concepts like biotech startup models, preteomic profiling for target identification, Gantt charts for project planning, etc.

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