genome-editing

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Human Genome Editing

Author : National Academies of Sciences, Engineering, and Medicine
ISBN : 9780309452885
Genre : Medical
File Size : 55. 83 MB
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Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Genome Editing

Author : Kiran Musunuru
ISBN : 9780128236475
Genre : Medical
File Size : 74. 7 MB
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Genome Editing: A Practical Guide to Research and Clinical Applications is geared towards investigators interested in learning how to use CRISPR-Cas9-based technologies, with a focus on cardiovascular research and clinical applications. Covering a range of topics from the basics of genome editing to design considerations, to assessments and applications, this reference allows readers to get started and establish a full workflow from the beginning of the project to its full completion. With worked examples drawn from real-life experiments, as well as troubleshooting and pitfalls to avoid, the book serves as an essential reference for researchers and investigators in both cardiovascular and biomedical research. Help readers familiarise with the variety of genome-editing approaches that are being applied in cardiovascular research and medicine, i.e., both research applications and clinical applications Understand the use of genome editing through worked examples (based on real-life experiments) in which CRISPR-Cas9 is employed, online tools to design CRISPR-Cas9 reagents, methods to interpret data from genome-editing experiments, the downsides of genome-editing technology - both the scientific and ethical pitfalls to avoid Written in an easy-to-follow manner, guiding readers from the design of the project to its completion Includes unpublished and new methods

Genome Editing In Neurosciences

Author : Rudolf Jaenisch
ISBN : 9783319601922
Genre : Medical
File Size : 24. 25 MB
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This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

100 Questions And Answers About Muscular Dystrophy

Author : Kathryn Wagner
ISBN : 9781284201666
Genre : Medical
File Size : 89. 7 MB
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EMPOWER YOURSELF! According to the National Organization for Rare Disorders (NORD), over 250,000 people are affected by muscular dystrophies (MD) in the United States, including Duchenne muscular dystrophy (DMD), myotonic muscular dystrophy (DM), facioscapulohumeral muscular dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) among many others. No one with MD needs to be alone in their fight against this rare disorder. That's where this book and the authoritative information within can help. 100 Questions & Answers About Muscular Dystrophy offers essential and practical guidance. This unique book provides both doctor and patient perspectives and offers answers to the most asked questions by patients and their loved ones. Is it safe to exercise? How do I find a clinical trial in which to participate? What are some things to remember when going to the emergency department? What can I do about fatigue? Along with the answers to these and other questions, this book provides information on diagnosis, treatment, living with MD, new therapeutic options, and more. Written by a leading expert on the topic with more than 20 years experience caring for patients with MD, 100 Questions & Answers About Muscular Dystrophy is an easy-to-read book and must-have resource for those living with MD, as well as their loved ones.

The Power Of Ethics

Author : Susan Liautaud
ISBN : 9781982132194
Genre : Philosophy
File Size : 22. 38 MB
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The essential guide for ethical decision-making in the 21st century. It’s not your imagination: we’re living in a time of moral decline. Publicly, we’re bombarded with reports of government leaders acting against the welfare of their constituents; companies prioritizing profits over health, safety, and our best interests; and technology posing risks to society with few or no repercussions for those responsible. Personally, we may be conflicted about how much privacy to afford our children on the internet; how to make informed choices about our purchases and the companies we buy from; or how to handle misconduct we witness at home and at work. How do we find a way forward? Today’s ethical challenges are increasingly gray, often without a clear right or wrong solution, causing us to teeter on the edge of effective decision-making. With concentrated power structures, rapid advances in technology, and insufficient regulation to protect citizens and consumers, ethics are harder to understand than ever. But in The Power of Ethics, Susan Liautaud shows how ethics can be used to create a sea change of positive decisions that can ripple outward to our families, communities, workplaces, and the wider world—offering unprecedented opportunity for good. Drawing on two decades as an ethics advisor guiding corporations and leaders, academic institutions, nonprofit organizations, and students in her Stanford University ethics courses, Susan Liautaud provides clarity to blurry ethical questions, walking you through a straightforward, four-step process for ethical decision-making you can use every day. Liautaud also explains the six forces driving virtually every ethical choice we face. Exploring some of today’s most challenging ethics dilemmas and showing you how to develop a clear point of view, speak out with authority, make effective decisions, and contribute to a more ethical world for yourself and others, The Power of Ethics is the must-have ethics guide for the 21st century.

Carbon Nanomaterials For Agri Food And Environmental Applications

Author : Kamel Ahmed Abd-Elsalam
ISBN : 9780128197868
Genre :
File Size : 21. 36 MB
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Carbon Nanomaterials for Agri-food and Environmental Applications discusses the characterization, processing and applications of carbon-based nanostructured materials in the agricultural and environmental sectors. Sections discuss the synthesis and characterization of carbon nanotubes, the technological developments in environmental applications of carbon-based nanomaterials, and agri-food applications. The book also covers the toxic effects of engineered carbon nanoparticles on the environment, and in plants and animals. Finally, quality control and risk management are addressed to assess health and environmental risks. This is an applicable book for graduate students, researchers and those in industrial sectors of science and technology who want to learn more about carbon nanomaterials. Compares a range of carbon-based nanomaterials, showing how they are used for a range of agricultural and environmental applications Discusses the challenges and toxicity of different types of carbon-based nanomaterials for environmental and agricultural applications Explores when different classes of nanomaterial should be used in different environments

Bioethics And Public Health Law

Author : Mary Anne Bobinski
ISBN : 9781454890416
Genre : Law
File Size : 63. 27 MB
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Financial and ethical issues are integrated into this concise and engaging treatment of Bioethics and Public Health Law. The complex relationship between patients, providers, the state, and public health institutions are explored through high-interest cases, informative notes, and compelling problems. The updated Fourth Edition includes recent cases and developments in biotechnology, including stem cell research and gene patents, and updates to HIPPA coverage, DNA research, and bio-banks. Discussions of confidentiality and informed consent include new legislative and judicial responses to posthumous reproduction and the challenges arising from international reproductive tourism.

Development Of Novel Crispr Technologies For The Precise Genome Editing Of Human Pluripotent Stem Cells

Author : Jared Matthew Carlson-Stevermer
ISBN : OCLC:1141859680
Genre :
File Size : 63. 79 MB
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Precision genome surgery has the potential to revolutionize the field of personalized medicine through applications ranging from basic science, to creation of in vitro disease models, all the way to the correction of genetic disease in vivo. Although the field has rapidly advanced since the development of CRISPR-based technology, the ability to generate precise edits at multiple locations within the genome remains an outstanding challenge. As a result, edited cell populations as well as isolated clones must be rigorously screened for the presence of undesired mutations before any form of clinical application such as ex vivo cell therapy or in vivo somatic cell editing can be undertaken. Thus, there is a need to increase rates of precise editing and decrease rates of imprecise mutation to improve the clinical viability of gene editing. This thesis aims to develop new technologies to address challenges in precision genome editing and subsequently demonstrate their utility in a human pluripotent stem cell disease model. First, I describe a method to track hundreds of cell populations in real time using high-content analysis, allowing the facile selection of those that have undergone genome editing. Second, I demonstrate a new technology that is capable of tethering together CRISPR ribonucleoproteins and donor DNA to increase the frequency of precise gene surgery. Finally, I combine these technologies to correct mutations in an induced pluripotent stem cell model of Pompe disease, an autosomal recessive disorder. These methods and their applications demonstrate advances in the field of precision genome surgery and represent an important step toward the clinical use of genetic therapies.

Genome Editing

Author : Kursad Turksen
ISBN : 9783319341484
Genre : Science
File Size : 63. 15 MB
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This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions. Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.

Tomorrow S Table

Author : Pamela C. Ronald
ISBN : 9780199342105
Genre : Technology & Engineering
File Size : 67. 89 MB
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"Tomorrow's Table" argues that a judicious blend of two important strands of agriculture--genetic engineering and organic farming--is key to helping feed the world's growing population in an ecologically balanced manner. Pamela Ronald, a geneticist, and her husband, Raoul Adamchak, an organic farmer, take the reader inside their lives for roughly a year, allowing us to look over their shoulders so that we can see what geneticists and organic farmers actually do. Readers see the problems that farmers face, trying to provide larger yields without resorting to expensive or environmentally hazardous chemicals--a problem that will loom larger and larger as the century progresses--and they learn how organic farmers and geneticists address these problems. The book is for consumers, farmers, and policy decision makers who want to make food choices and policy that will support ecologically responsible farming practices, and for anyone who wants accurate information about organic farming, genetic engineering, and their potential impacts on human health and the environment. The first edition was published in hardcover in 2008 and in paperback in 2009. This second edition reflects the many and varied changes the fields of farming and genetic engineering have seen since 2009. It includes a new preface and three new chapters-one on politics and food-related protests such as the Marin county anti-vaccine movement and the subsequent outbreak of whooping cough, one on farming and food security, and one containing various recipes. Existing chapters on the tools of genetic engineering, organic vs. conventional foods, the tools of organic agriculture, and food labeling and legislature have all been updated.

Genome Editing

Author : Toni Cathomen
ISBN : 9781493935093
Genre : Medical
File Size : 89. 80 MB
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This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integrases, triplex forming oligonucleotides and peptide nucleic acids, aptamer-guided gene targeting, AAV gene editing via DSB repair, engineered nucleases and trinucleotide repeat diseases, and creation of HIV-resistant cells. The expertly authored chapters contextualize current developments within the history of genome editing while also discussing the current and potential safety concerns of this rapidly growing field. Genome Editing: The Next Step in Gene Therapy, the latest volume in the American Society of Gene and Cell Therapy series, deftly illuminates the potential of genetic engineering technology to eradicate today’s deadliest and most prolific diseases. It is ideal reading for clinicians and researchers in genetics and immunology.

Genome Editing Technologies And Their Impact

Author : Institut d'Estudis Catalans
ISBN : 9788499655642
Genre : Science
File Size : 39. 17 MB
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Genome Editing And Engineering

Author : Krishnarao Appasani
ISBN : 9781316762080
Genre : Science
File Size : 57. 74 MB
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Recent advances in genome editing tools using endonucleases such as TALENs, ZFNs, and CRISPRs, combined with genomic engineering technologies, have opened up a wide range of opportunities from applications in the basic sciences and disease biology research, to the potential for clinical applications and the development of new diagnostic tools. This complete guide to endonuclease-based genomic engineering gives readers a thorough understanding of this rapidly expanding field. Chapters cover the discovery, basic science, and application of these techniques, focusing particularly on their potential relevance to the treatment of cancer, and cardiovascular and immunological disease. The final section discusses the legal and ethical issues which accompany the technology. Providing authoritative coverage of the potential that genome editing and engineering have, this is an ideal reference for researchers and graduate students and those working in the biotechnology and pharmaceutical industries, as well as in a clinical setting.

Crispr Cas Genome Editing

Author : Anjanabha Bhattacharya
ISBN : 9783030420222
Genre : Science
File Size : 87. 93 MB
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This book offers a comprehensive collection of papers on CRISPR/Cas genome editing in connection with agriculture, climate-smart crops, food security, translational research applications, bioinformatics analysis, practical applications in cereals, floriculture crops, engineering plants for abiotic stress resistance, the intellectual landscape, regulatory framework, and policy decisions. Gathering contributions by internationally respected experts in the field of CRISPR/Cas genome editing, the book offers an essential guide for researchers, students, teachers and scientists in academia; policymakers; and public companies, private companies and cooperatives interested in understanding and/or applying CRISPR/Cas genome editing to develop new agricultural products.

Genome Editing With Crispr Cas9

Author :
ISBN : OCLC:1157671045
Genre : Gene editing
File Size : 72. 72 MB
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Genome Editing

Author : Gurbachan S. Miglani
ISBN : 1783323965
Genre : Technology & Engineering
File Size : 63. 54 MB
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"Genome editing: A Comprehensive Treatise provides concise knowledge on genetic manipulation of genome, accomplished in nuclear as well as organellar genomes. Basic principles of genome editing involve induction of double-stranded DNA breaks, with the help of engineered sit-specific thereby induce site-specific deletions, insertions, disruptions, etc. Hence, it is developed under the broader approach of genome engineering. This book is specially designed as a textbook and reference book, as well. The book will be useful for upper undergraduate and graduate students studying genome editing in agricultural, veterinary and medicinal universities. Teachers and researchers in many disciplines will also get benefited from this book. Salient features: DNA repair mechanisms involved in genome editing discussed. Different types of oligonucleotides and animals and plant viruses that have been modified to act as donor DNA molecules described. Detailed discussions on Gene drives, gene expression control, safety issues, regulatory issues and future of genome-editing technology. Include 2530 references, 50 tables and 261 figures. Problems listed at the end of each chapter"--Back cover.

A Crack In Creation

Author : Jennifer A. Doudna
ISBN : 9780544716964
Genre : Science
File Size : 34. 12 MB
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BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY Finalist for the Los Angeles Times Book Prize “The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas “Required reading for every concerned citizen.” — New York Review of Books Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna—who has since won the Nobel Prize for her CRISPR research—shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life. “An invaluable account . . . We owe Doudna several times over.” — Guardian

Precise Genome Editing Techniques And Applications

Author : Zhiying Zhang
ISBN : 9782889637799
Genre :
File Size : 66. 52 MB
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Chancen Und Grenzen Des Genome Editing

Author :
ISBN : 3804734936
Genre :
File Size : 67. 21 MB
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Heritable Human Genome Editing

Author : The Royal Society
ISBN : 9780309671132
Genre : Medical
File Size : 78. 99 MB
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Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

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