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Biopharmaceutics And Clinical Pharmacokinetics

Author : Notari
ISBN : 0824775236
Genre : Science
File Size : 30. 50 MB
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Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface to the Fourth Edition -- Preface to the Third Edition -- Preface to the Second Edition -- Preface to the First Edition -- Nomenclature -- 1: Introduction -- References -- 2: Rates, Rate Constants, and Order -- I. Order -- II. Rates and Rate Constants -- 3: Active and Passive Transport -- I. Introduction -- II. Passive Transport -- III. Active Transport -- References -- 4: Pharmacokinetics -- I. Introduction -- II. Drug Disposition -- III. Constant-Rate Intravenous Infusion -- IV. Compartmental Models and Their Limitations -- V. Absorption Rate Constants -- References -- 5: Biopharmaccutics -- I. Extravascular Administration -- II. Absorption of Drugs from the Gastrointestinal Tract -- III. Factors Influencing Bioavailability -- IV. Evaluation of the Bioavailability of a Single Drug -- V. Drug Delivery to Prolong Duration -- References -- 6: Dosage Regimens -- I. Introduction -- II. Accumulation During Repetitive Dosing -- III. Adjustment of Dosage Regimen in Renal Failure -- IV. Multiple Dosing of Constant-Rate Intravenous Infusions -- References -- 7: Pharmacokinetic Aspects of Structural Modifications in Drug Design and Therapy -- I. Introduction -- II. Antimicrobial Agents -- III. Pharmacokinetics of Prodrugs -- IV. Stereoisomers -- References -- 8: Pharmacokinetic Applications in Clinical Practice -- I. Introduction -- II. Pharmacokinetic Drug Interactions -- III. Clinical Pharmacokinetics -- References -- Appendix -- Index

Biopharmaceutics And Clinical Pharmacokinetics

Author : Milo Gibaldi
ISBN : UOM:39015018883739
Genre : Medical
File Size : 58. 10 MB
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This updated introduction to the clinical applications of pharmacokinetics looks at gastrointestinal absorption, prolonged release medication, and drug disposition. The effects of disease, weight, age, sex and genetic factors on pharmacokinetic variability and drug response are detailed. Bioequivalence and regulatory considerations for generic drug.

Essentials Of Biopharmaceutics And Pharmacokinetics E Book

Author : Ashutosh Kar
ISBN : 9788131232620
Genre : Medical
File Size : 52. 12 MB
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Essentials of Biopharmaceutics and Pharmacokinetics Kar’s Essentials of Biopharmaceutics and Pharmacokinetics deals with how a drug exerts its action in the human body through the fundamentals of absorption, distribution, metabolism and excretion. The book adopts a growth-oriented format and design that is developed systematically and methodically. The book interrelates five different sections: Section 1 Biopharmaceutics and Pharmacokinetics: What Do They Mean? Section 2 Biopharmaceutics Section 3 Pharmacokinetics Section 4 Clinical Pharmacokinetics Section 5 Bioavailability and Bioequivalence Each section starts with a basic theory and fields of application, focuses on model-independent pharmacokinetic analyses, expatiates various biopharmaceutical aspects of dosage form and evaluation, provides an altogether new approach in understanding both dosage regimen design and individualization, and explains modification in drug molecules related to the pharmacokinetics. Undoubtedly, the unique blend of fundamental principles and latest breakthroughs in the field will certainly provide sufficient subject matter to the students of pharmacy, pharmacology, medicinal chemistry scientists, who need a simple as well as detailed introduction in theory and application.

Textbook Of Biopharmaceutics And Clinical Pharmacokinetics

Author :
ISBN : 9381075042
Genre :
File Size : 89. 39 MB
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Applied Biopharmaceutics Pharmacokinetics Eigth Edition

Author : Andrew B.C. Yu
ISBN : 126014299X
Genre : Medical
File Size : 49. 21 MB
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Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. This authoritative guide has been updated with important new findings about drug therapy, product performance, and other need-to-know topics Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition delivers the knowledge and skills you need to succeed. The authors provide practical problems with specific examples of clinical solutions to help you apply principles to patient care and drug consultation situations. Each chapter includes objectives, summaries, and FAQs highlighting that help you understand and retain key concepts. You’ll learn how to derive models/parameters to describe drug absorption, distribution, and elimination processes; evaluate biopharmaceutic studies involving drug product equivalency and unequivalency; design and evaluate dosage regimens of drugs; detect and solve clinical pharmacokinetic problems; and much more.

Applied Biopharmaceutics Pharmacokinetics Seventh Edition

Author : Leon Shargel
ISBN : 9780071829649
Genre : Medical
File Size : 27. 26 MB
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The landmark textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics—now fully updated. Explains how to detect clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them Helps you critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency Chapters have been revised to reflect the latest clinical perspectives on drug performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy The field’s leading text for more than three decades, Applied Biopharmaceutics & Pharmacokinetics gets you up to speed on the basics of the discipline like no other resource. Practical problems and clinical examples with discussions are integrated within each chapter to help you apply principles to patient care and drug consultation situations. In addition, outstanding pedagogy, including chapter objectives, chapter summaries, and FAQs, plus additional application questions, identify and focus on key concepts. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics shows you how to use raw data and formulate the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination. The book also helps you work with pharmacokinetic and biopharmaceutic parameters to design and evaluate dosage regimens of drugs. In the seventh edition of this must-have interactive learning tool, most of the chapters are updated to reflect our current understanding of complex issues associated with safe and efficacious drug therapy.

Applied Biopharmaceutics Pharmacokinetics Sixth Edition

Author : Leon Shargel
ISBN : 9780071603935
Genre : Medical
File Size : 41. 42 MB
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A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics The field’s leading text for more than three decades Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to: Understand the basic concepts in biopharmaceutics and pharmacokinetics. Use raw data and derive the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination Critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency Design and evaluate dosage regimens of drugs, using pharmacokinetic and biopharmaceutic parameters Detect potential clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them Practical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy.

Shargel And Yu S Applied Biopharmaceutics Pharmacokinetics 8th Edition

Author : Leon Shargel
ISBN : 9781260143003
Genre : Medical
File Size : 61. 81 MB
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The authoritative textbook on the principles and practical applications of biopharmaceutics and pharmacokinetics Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics has been the standard textbook in its field for over 40 years. This eighth edition includes recent scientific developments in the field and embodies the collective contribution of experts with deep knowledge and experience in the selected subject areas. Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition provides the reader with a fundamental understanding of biopharmaceutics and pharmacokinetics principles that can be applied to patient drug therapy and rational drug product development. Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition has been expanded and revised to include advancements in biopharmaceutics and pharmacokinetics. The chapter sequence has been reorganized into four main sections, providing a more logical sequence for students. The textbook starts with fundamental concepts, followed by application of these principles to optimize drug therapy and to the rational development of drug products. Each chapter includes theoretical concepts with practical examples and clinical applications. Frequently asked questions provide a discussion of overall concepts. Features: Expanded and revised chapters to include scientific advances in biopharmaceutics and pharmacokinetics Four main sections providing a natural buildup of knowledge: introduction to biopharmaceutics and pharmacokinetics, fundamentals of biopharmaceutics, pharmacokinetic calculations, clinical pharmacokinetics and pharmacodynamics, and biopharmaceutics and pharmacokinetics in drug product development Additional chapters for this edition include: o Physiological factors related to drug absorption o Approaches to pharmacokinetics and pharmacodynamics calculations o Novel and complex dosage Forms o Clinical Development and Therapeutic Equivalence of Generic Drug and Biosimilar Products o Pharmacokinetics and Pharmacodynamics in Clinical Drug Product Development Additional information on drug therapy, drug product performance, and other related topics Frequently asked questions, practice problems, clinical examples and learning questions

Biopharmaceutics And Relevant Pharmacokinetics

Author : John G. Wagner
ISBN : UOM:39015010669912
Genre : Biopharmaceutics
File Size : 72. 78 MB
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Clinical Pharmacokinetics

Author : Stephen H. Curry
ISBN : 0936923024
Genre : Medical
File Size : 65. 90 MB
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Clinical Pharmacokinetics: The MCQ Approach is a self-teaching guide to the subject. The reader is guided through the principles of the subject as they are applied to increasingly complex situations. The volume contains a number of single and multiple-choice questions, many requiring graphing and calculation techniques and is intended as an instructional tool both for the student and practicing professional. The volume aims to test to reader's analytical skills when presented with experimental data. It will be of interest to students of pharmacy, clinical pharmacology and biopharmaceutics as well as to instructors in those subjects, both in the teaching of the subject and in the design of examination material.

Biopharmaceutics And Pharmacokinetics

Author : J. S. Kulkarni
ISBN : 8123913079
Genre : Medical
File Size : 58. 9 MB
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Biopharmaceutics and Pharmacokinetics deals with what body does to the drug. In this book, along with the fundamentals of absorption, distribution, metabolism and excretion, current topics such as in vitro systems have also been introduced. In case of pharmacokinetics models, authors have tried to keep mathematical part simpler and minimal. This book also introduces "non compartmental models", which are gaining increasing importance in the analysis of pharmacokinetic data. In the chapter "applications of pharamacokinetics", newer concepts such as chronopharmacokinetics have been introduced. Bioequivalence is covered in last two chapters. Besides clinical aspects of bioequivalence, some of the important aspects of bioanalysis have also been introduced. The regulatory aspect of bioequivalence has also been covered. Thus an attempt has been made to cover all the basic aspects of biopharmaceutics and pharmacokinetics in a reader-friendly manner.

Biopharmaceutics And Clinical Pharmacokinetics

Author : Robert E. Notari
ISBN : UOM:39015000863343
Genre : Biopharmaceutics
File Size : 52. 78 MB
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1 Bioavailability 1; 2. Rate processes in biological systems 5; 3. Principles of pharmacokinetics 45; 4. Biopharmaceutics: clinical applications of pharmacokinetic parameters 107; 5. Dosage regimens 173; 6. Pharmacokinetic aspects of structural modification in drug design and therapy 213; 7. An overview of pharmacokinetic applications in clinical practice 290; Appendix A: Fick's law 338; Appendix B: Vd 341; Appendix C: Area under I.V. curves 346; Appendix D: Multiple-dose equations 348; Appendix E: List of symbols of general occurrence 351.

Basic Pharmacokinetic Concepts And Some Clinical Applications

Author : Tarek A Ahmed
ISBN : 9789535121978
Genre : Medical
File Size : 25. 44 MB
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This book considers the basic principles of biopharmaceutics and pharmacokinetics. It also illustrates clinical pharmacokinetic applications, such as recirculatory models, common antimalarial drugs, and clinical pharmacokinetic principles in critically ill patients, which are essential for medical professionals. Undergraduate and postgraduate students can make use of the information presented. The contents of the book represent the authors points of view as well as clinical findings and basic concepts of pharmacokinetics and biopharmaceutics that are covered in textbooks.

Textbook Of Biopharmaceutics And Clinical Pharmacokinetics

Author : Sarfaraz Niazi
ISBN : UOM:39015006046182
Genre : Biopharmaceutics
File Size : 73. 16 MB
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Applied Biopharmaceutics Pharmacokinetics

Author : Leon Shargel
ISBN : UOM:39015046909456
Genre : Medical
File Size : 32. 2 MB
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This new edition emphasizes the application and understanding of basic theoretical principles of biopharmaceutics and pharmacokinetics. Now with a second highlight color, this book helps students gain skills in problem solving and includes examples and practice problems and solutions.

Concepts In Clinical Pharmacokinetics

Author : William J. Spruill
ISBN : 1585283878
Genre : Medical
File Size : 72. 12 MB
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Preceded by Concepts in clinical pharmacokinetics / Joseph T. DiPiro ... [et al.].

Biopharmaceutics

Author : Hannah Batchelor
ISBN : 9781119678281
Genre : Medical
File Size : 51. 26 MB
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Explore the latest research in biopharmaceutics from leading contributors in the field In Biopharmaceutics - From Fundamentals to Industrial Practice, distinguished Scientists from the UK's Academy of Pharmaceutical Sciences Biopharmaceutica Focus Group deliver a comprehensive examination of the tools used within the field of biopharmaceutics and their applications to drug development. This edited volume is an indispensable tool for anyone seeking to better understand the field of biopharmaceutics as it rapidly develops and evolves. Beginning with an expansive introduction to the basics of biopharmaceutics and the context that underpins the field, the included resources go on to discuss how biopharmaceutics are integrated into product development within the pharmaceutical industry. Explorations of how the regulatory aspects of biopharmaceutics function, as well as the impact of physiology and anatomy on the rate and extent of drug absorption, follow. Readers will find insightful discussions of physiologically based modeling as a valuable asset in the biopharmaceutics toolkit and how to apply the principles of the field to special populations. The book goes on to discuss: Thorough introductions to biopharmaceutics, basic pharmacokinetics, and biopharmaceutics measures Comprehensive explorations of solubility, permeability, and dissolution Practical discussions of the use of biopharmaceutics to inform candidate drug selection and optimization, as well as biopharmaceutics tools for rational formulation design In-depth examinations of biopharmaceutics classification systems and regulatory biopharmaceutics, as well as regulatory biopharmaceutics and the impact of anatomy and physiology Perfect for professionals working in the pharmaceutical and biopharmaceutical industries, Biopharmaceutics - From Fundamentals to Industrial Practice is an incisive and up-to-date resource on the practical, pharmaceutical applications of the field.

Biopharmaceutics And Pharmacokinetics

Author : Sayed Mohamed Ahmed
ISBN : 3659301906
Genre :
File Size : 48. 50 MB
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This book is essential for pharmaceutical, medical, technological and clinical research undergraduate and postgraduate courses. It is one of the essential courses for students of medicine and pharmacy all over the world. This book was written specially keeping in mind the syllabi for Pharmacy, Medical and Nursing students. It is also useful to scientist working in the pharmaceutical industry. In the field of research, no one can accomplish pharmaceutical, medical or clinical research in Vivo or in Vitro article, master or Ph.D. thesis without reading the basics of "Biopharmaceutics and pharmacokinetics." Even though, this book is critically essential for any person who needs to understand the scientific basics for the effect of drugs on our body. Finally, we believe that any pharmacist or physician, either clinical, hospital, community, or manufacturing, has to stick to this book in order to obtain the highest outcome of the medicines they prescribe, manufacture or handle. Patients who are looking for getting the best benefit from drugs they administer have to read that book to improve their knowledge.

Biopharmaceutics And Pharmacokinetics

Author : PL Madan
ISBN : 9350909391
Genre : Medical
File Size : 54. 76 MB
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Biopharmaceutics And Pharmacokinetics Considerations

Author :
ISBN : 9780128144268
Genre : Medical
File Size : 64. 79 MB
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Biopharmaceutics and Pharmacokinetics Considerations examines the history of biopharmaceutics and pharmacokinetics. The book provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce. Examines the most recent developments in biopharmaceutics and pharmacokinetics for pharmaceutical sciences Covers the principles, methodologies and technologies of biopharmaceutics and pharmacokinetics Focuses on the pharmaceutical sciences, but also encompasses aspects of toxicology, neuroscience, environmental sciences and nanotechnology

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